|
KMID : 0616619970030010241
|
|
Journal of Soonchunhyang Medical College
1997 Volume.3 No. 1 p.241 ~ p.248
|
|
|
Relation between Severity of Morning Sickness and Thyroid Function in Normal Early Pregnancy
|
|
|
|
|
Abstract
|
|
|
Nausea and vomiting are extremely common symptoms in first trimester of the pregnancy. The reported frequency is ranging from 50-75% of all pregnancy.
Hyperemesis gravidarum is clinically characterized by profuse vomiting which may some time be so severe as to cause electrolytes imbalance especially hypokalemia which can be like threatening or even fatal requiring hospitalization and intravenous therapy.
Pregnant women with severe emesis might have a similar condition of non-thyroidal illness. However, little is known about the relation between morning sickness and thyroid function. Mori(1988) reported that increased free T₄and hCG and decreased TSH correlated with the severity of morning sickness, and these changes were especially marked in subject with nausea and vomiting. Thyroid gland is physiologically activated in early pregnancy, possibly by hCG or related substance, which may be gestational emesis.
The purpose of this study was to determine thyroid function in early pregnancy with reference to morning sickness, using a highly sensitive immunoradiometric assay for TSH and a newly developed free T₄RIA that is not influenced by changes in thyroxine-binding globulin or albumin.
The results were as follows:
1. Among groups in early pregnancy, the severity of morning sickness correlated significantly with changes of free T₄(p<0.05), TSH(p<0.01) and hCG(p<0.05)
2. The serum levels of free T₄in all 100 pregnant women correlated negatively with their TSH level (r=-0.451, p<0.001) and positively with their hCG levels (r=0.292, p<0.05). More their serum TSH levels correlated negatively with hCG levels(r=-0.279, p<0.05)
3. The increased free T₄and decreased TSH in subjects with emesis returned to the normal ranges of nonpregnant controls after improvement of emesis in five normal pregnant women.
4. An increased level of free T₄and a reduced level of TSH in early normal pregnancy are not indication of thyrotoxicosis and may not necessitate antithyroid drug treatment.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|